• Silva JA, Tecuapetla F, Paixão VB, Costa, RM (2017). Dopamine neuron activity before action initiation gates and invigorates future movements. Nature, in press. 

  • Afonso C, Paixão VB, Klaus A, Lunghi M, Piro F, Emiliani C, di Cristina M, Costa RM (2017). Toxoplasma-induced changes in host risk behaviour are independent of parasite-derived AaaH2 tyrosine hydroxylase. Scientific Reports, 7(1):13822. doi: 10.1038/s41598-017-13229-y. 

  • Klaus, A*, Martins, GJM*, Paixão VB, Zhou, P, Paninski, L, Costa, RM (2017). The spatiotemporal organization of the striatum encodes action space. Neuron, 95(5):1171-1180.e7. doi: 10.1016/j.neuron.2017.08.015

  • Galvão-Ferreira P, Lipinski M, Santos F, Barco A, Costa RM (2017). Skill Learning Modulates RNA Pol II Poising at Immediate Early Genes in the Adult Striatum. eNeuro, 17;4(2). doi: 10.1523/ENEURO.0074-17.2017. 

  • Athalye VR, Ganguly K, Costa RM*, Carmena JM* (2017). Emergence of Coordinated Neural Dynamics Underlies Neuroprosthetic Learning and Skillful Control. Neuron,  93(4):955-970.  doi: 10.1016/j.neuron.2017.01.016. 

  • Tecuapetla, F, Jin, X., Lima, SQ, Costa, RM (2016). Complementary contributions of striatal projection pathways to action initiation and execution. Cell, 166(3):703-15. doi: 10.1016/j.cell.2016.06.032. 

  • Gremel CM, Chancey J, Atwood B, Luo G, Neve R, Ramakrishnan C, Deisseroth K, Lovinger DM, Costa RM (2016). Endocannabinoid modulation of orbitostriatal circuits gates habit formation. Neuron, 90(6):1312-24. doi: 10.1016/j.neuron.2016.04.043. 

  • Vicente, AM*, Galvão-Ferreira, P*, Tecuapetla, F, Costa, RM (2016). Direct and indirect striatal projection pathways reinforce different action strategies. Current Biology, 26(7):R267-9. doi: 10.1016/j.cub.2016.02.036. 

  • Akam, T, Costa RM, Dayan P (2015). Simple Plans or Sophisticated Habits? State, Transition and Learning Interactions in the Two-step Task. PLoS Computational Biology, 11(12):e1004648. doi: 10.1371/journal.pcbi.1004648. 

  • Santos F, Jin X, Oliveira, R, Costa RM (2015). Corticostriatal dynamics encode the refinement of behavioral variability during skill learning. eLife, 4:e09423. doi:10.7554/eLife.09423. 

  • Cao VY, Ye Y, Mastwal S, Ren M, Coon M, Liu Q, Costa RM*, Wang KH* (2015). Motor Learning Consolidates Arc-expressing Neuronal Ensembles in Secondary Motor Cortex. Neuron, 86(6):1385-92. doi: 10.1016/j.neuron.2015.05.022. 

  • Tecuapetla F, Matias S, Dugue GP, Mainen ZF, Costa RM (2014). Balanced activity in basal ganglia projection pathways is critical for contraversive movements. Nature Communications, 5:4315. doi: 10.1038/ncomms5315. 

  • Cui G, Jun SB, Jin X, Pham MD, Vogel SS, Lovinger DM, Costa RM (2014). Deep brain optical measurement of cell type-specific neural activity in mice performing an operant task. Nature Protocols, 9(6):1213-28. doi: 10.1038/nprot.2014.080. 

  • Clancy KB, Koralek AC, Costa RM*, Feldman DE*, Carmena JM*. (2014). Volitional modulation of optically recorded calcium signals during neuroprosthetic learning. Nature Neuroscience, 17(6):807-9. doi: 10.1038/nn.3712. 

  • Jin X, Tecuapetla F, Costa RM (2014). Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences. Nature Neuroscience, 17(3):423-30. doi: 10.1038/nn.3632. 

  • Gremel, CM & Costa RM (2013). Orbitofrontal and striatal circuits dynamically encode the shift between goal-directed and habitual actions. Nature Communications, 4:2264. doi: 10.1038/ncomms3264. 

  • Gremel CM & Costa RM (2013). Premotor cortex is critical for goal-directed actions. Frontiers in Computational Neuroscience, 7:110. doi: 10.3389/fncom.2013.00110. 

  • Koralek AC, Costa RM, Carmena JM (2013). Temporally precise cell-specific coherence develops in corticostriatal networks during learning. Neuron, 4;79(5):865-72.  doi: 10.1016/j.neuron.2013.06.047. 

  • Cao VY, Ye Y, Mastwal SS, Lovinger DM, Costa RM, Wang KH. (2013). In vivo two-photon imaging of experience-dependent molecular changes in cortical neurons. Journal of Visualized Experiments, 5;(71) pii: 50148. doi:10.3791/50148

  • Cui, G*, Jun SB*, Jin, X, Pham, MD, Vogel SS, Lovinger DM & Costa RM. (2013) Concurrent activation of striatal direct- and indirect-pathways during action initiation. Nature. 494(7436):238-42. doi: 10.1038/nature11846. 

  • Koralek, AC*, Jin, X*, Long II, JD, Costa RM*, Carmena JM*. (2012). Corticostriatal plasticity is necessary for learning intentional neuroprosthetic skills. Nature, 483(7389):331-5. doi: 10.1038/nature10845. 

  • Afonso C, Paixão VB, Costa, RM (2012). Chronic Toxoplasma Infection Modifies the Structure and the Risk of Host Behavior. PLoS One, 7(3):e32489. doi: 10.1371/journal.pone.0032489. 

  • Hilário, MR, Holloway, T, Jin, X, Costa, RM (2012). Different dorsal striatum circuits mediate action discrimination and action generalization. European Journal of Neuroscience, 35(7):1105-14. doi: 10.1111/j.1460-9568.2012.08073. 

  • French CA, Jin X, Campbell TG, Gerfen E, Groszer M, Fisher SE, Costa RM (2011). An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning. Molecular Psychiatry, 17(11):1077-85. doi: 10.1038/mp.2011.105. 

  • Jin X & Costa RM (2010). Start/stop signals emerge in nigrostriatal circuits during sequence learning. Nature;466(7305):457-62. doi: 10.1038/nature09263. 

  • Derusso AL, Fan D, Gupta J, Shelest O, Costa RM, Yin HH (2010). Instrumental uncertainty as a determinant of behavior under interval schedules of reinforcement. Frontiers in Integrative Neuroscience. 28;4. pii: 17. doi: 10.3389/fnint.2010.00017. 

  • Venkatraman S, Jin X, Costa RM, Carmena JM (2010). Investigating neural correlates of behavior in freely behaving rodents using inertial sensors. Journal Neurophysiology.104(1):569-75. doi: 10.1152/jn.00121.2010. 

  • Burkhardt, JM, Jin, X, and Costa RM (2009).  Dissociable effects of dopamine on neuronal firing rate and synchrony in dorsal striatum. Frontiers in Integrative Neuroscience 3:28. doi:10.3389/neuro.07.028.2009.  

  • Dias-Ferreira, E, Sousa, JC, Melo I, Morgado P, Mesquita, AR, Cerqueira JJ, Costa, RM*, Sousa N* (2009). Chronic stress causes frontostriatal reorganization and affects decision-making. Science, 325(5940):621-5. doi: 10.1126/science.1171203. 

  • Yin, HH, Prasad-Mulcare, S, Hilario, MRF, Clouse, E, Davis, MI, Lovinger, DM, Costa, RM (2009). Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill. Nature Neuroscience, 12(3):333-41. doi: 10.1038/nn.2261.  

  • Cui, Y, Costa RM, Murphy GG, Elgersma, Y, Zhu, Y, Gutmann, DH, Parada, LF, Mody, I, Silva AJ (2008). Neurofibromin regulation of Ras/ERK signaling modulates GABA release and learning. Cell, 31;135(3):549-60.  doi: 10.1016/j.cell.2008.09.060. 

  • Groszer, M, Keays, DA, Deacon RMJ, de Bono JP, Prasad-Mulcare S, Gaub, S, Baum, MG, French, CA, Nicod, J, Coventry, JA, Enard, W, Fray, M, Brown, SDM, Nolan, PM, Pääbo, S, Channon, KM, Costa, RM, Eilers, J, Ehret, G, J, Rawlins NP, Fisher, SE (2008). Impaired motor learning and synaptic plasticity in mice carrying a point mutation implicated in human speech deficits. Current Biology, 18(5):354-62. doi: 10.1016/j.cub.2008.01.060. 

  • Hilario, MRF., Clouse, E, Yin, HH, Costa, RM (2007). Endocannabinoid signaling is critical for habit formation. Frontiers in Integrative Neuroscience. 1:6, doi: 10.3389/neuro.07/006.2007. 

  • Costa, RM, Lin, SC, Sotnikova, TD, Cyr, M, Gainetdinov, RR, Caron, MG, Nicolelis MAL (2006). Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction. Neuron, 52(2):359-69. 

  • Dzirasa, K, Ribeiro. S, Costa, RM, Santos, LM, Lin, SC, Grosmark, A, Sotnikova, TD, Gainetdinov, RR, Caron, MG, Nicolelis MAL (2006). Dopaminergic control of sleep-wake states. Journal of Neuroscience, 26(41):10577-89. doi:10.1523/JNEUROSCI.1767-06.2006

  • Costa, RM, Gutierrez, R, Kloth, A, Coelho, MRP, de Araujo, IE, Gainetdinov, RR, Caron, MG, Nicolelis MAL, Simon, SA (2007). Dopamine levels modulate the updating of tastant values. Genes, Brain and Behavior, 6(4):314-20. 

  • Nagy, V, Bozdagi, O, Matynia, A, Balcerzyk, M, Okulski, P, Dzwonek, J, Costa, RM, Silva, AJ, Kaczmarek, L, and Huntley GW (2006). Matrix metalloproteinase (MMP)-9 is required for hippocampal late-phase LTP and memory. Journal of Neuroscience, 26: 1923-1934. doi: 10.1523/JNEUROSCI.4359-05.2006

  • Costa, RM, Liu, L, Nicolelis, MAL, Simon, SA (2005). Gustatory Effects of Capsaicin that are Independent of TRPV1 Receptors. Proc. ISOT XIV, Chemical Senses, 30 S1:i198-i200. 

  • Israely, I, Costa, RM, Silva, AJ, Kosik, K, Liu, X (2004). Deletion of the neural specific protein Delta-Catenin leads to severe cognitive and synaptic dysfunction. Current Biology, 14(18):1657-63. 



  • Costa, RM*, Cohen, D*, Nicolelis MAL (2004). Differential corticostriatal plasticity during fast and slow motor skill learning in mice.  Current Biology, 14(13):1124-34. 

  • Costa RM, Honjo T, and Silva AJ (2003). Learning and memory deficits in Notch mutant mice. Current Biology, 13 (15):  1348-54. 

  • Ajay A, Costa RM, Irvin D, Patel A, Hu H, Kornblum H, Silva AJ, O’Dell T, and Colicelli J (2003). The RAS Effector RIN1 Modulates the Formation of Aversive Memories. Journal of Neuroscience, 23 (3): 748-757. 

  • Costa, RM, Federov, NB, Kogan, JH, Murphy, GG, Stern, J, Ohno, M, Kucherlapati, R, Jacks, T and Silva, AJ (2002). Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature, 415 (6871):526-30.  

  • Givogri MI, Costa RM, Schonmann V, Howard S, Silva AJ, Campagnoni AT, Bongarzone ER (2002). The Jagged/Notch pathway is critical for oligodendrocyte differentiation and myelination in vivo. Journal of Neuroscience Research, 67 (3):309-20.  

  • Ohno, M, Frankland, PW, Chen, PA, Costa RM and Silva AJ (2001). Inducible pharmacogenetic approaches to the study of learning and memory. Nature Neuroscience, 4(12): 1238-1243. 

  • Costa, RM*, Yang, T*, Huynh, DP, Pulst S.M., Viskochil, DH, Silva, AJ and Brannan, CI (2001). Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of the Neurofibromatosis type I gene. Nature Genetics, 27(7): 399-405. 

  • Mayntz, M and Costa, R (1998). Effect of pharmacologically induced changes of ejection on suckling in Bos taurus. Physiology and Behavior, 65 (1), 151-156. 

  • Costa, R, Mayntz, M and Sender, G (1998). Changes of milk compounds and fatty acid composition during suckling meals and the effect of after-stimulation on fatty acid composition in cows' milk. A pre-study. Milchwissenchaft, 53 (8), 430-434. 

Review Papers and Proceedings

  • Goncalves SB, Ribeiro JF, Silva AF, Costa RM, Correia JH (2017). Design and manufacturing challenges of optogenetic neural interfaces: a review. Journal of Neural Engineering, 14(4):041001. doi: 10.1088/1741-2552/aa7004. 

  • Khanna P, Athalye VR, Gowda S, Costa RM, Carmena JM (2016).  Modeling distinct sources of neural variability driving neuroprosthetic control. Conf Proc IEEE Engineering in Medicine Biology Society, 2016:3068-3071. doi: 10.1109/EMBC.2016.7591377. 

  • Jin, X and Costa RM (2015). Shaping action sequences in basal ganglia circuits. Current Opinion in Neurobiology, 33:188-96. doi: 10.1016/j.conb.2015.06.011. 

  • Gomez-Marin A, Paton JJ, Kampff AR, Costa RM, Mainen ZF (2014). Big behavioral data: psychology, ethology and the foundations of neuroscience. Nature Neuroscience, 17(11):1455-62. doi: 10.1038/nn.3812

  • Akam T, Costa RM. (2014). When brains flip coins. Neuron, 1;84(1):9-11. doi: 10.1016/j.neuron.2014.09.025

  • da Silva JA, Costa RM (2012). Bursting for exploration. Nature Neuroscience, 15(9):1178-9. doi: 10.1038/nn.3198. 

  • Vicente AM, Costa, RM (2012). Looking at the trees in the central forest: a new pallidal-striatal cell type. Neuron, 74(6):967-9. doi: 10.1016/j.neuron.2012.06.003. 

  • Dias-Ferreira E, Costa RM (2012). The symphony of choice. Nature, 4;484(7392):42-3.  doi: 10.1038/484042a. 

  • Santos, FJ, Costa, RM, Tecuapetla, F. (2011). Stimulation on demand: closing the loop on deep brain stimulation. Neuron, 72(2):197-8. doi: 10.1016/j.neuron.2011.10.004. 

  • Costa, RM (2011). A selectionist account of de novo action learning. Current Opinion Neurobiology, 21(4):579-86. doi: 10.1016/j.conb.2011.05.004.  

  • Dias-Ferreira E, Sousa N, Costa RM (2010). Frontocerebellar Connectivity: Climbing through the Inferior Olive. Frontiers Neuroscience, 15;4. pii: 37. doi: 10.3389/fnins.2010.00037. 

  • Koralek AC, Long JD, Costa RM, Carmena JM (2010). Corticostriatal dynamics during learning and performance of a neuroprosthetic task. Conf Proc IEEE Engineering in Medicine Biology Society, 2010:2682-5. doi: 10.1109/IEMBS.2010.5626632. 

  • Hilário, MRF and Costa, RM (2008). High on Habits. Frontiers in Neuroscience, 2(2):208-17.  doi: 10.3389/neuro.01.030.2008.  

  • Wickens, JR, Horvitz, JC, Costa, RM, Killcross, S (2007). Dopaminergic mechanisms in actions and habits. Journal of Neuroscience, 27:8181-3

  • Costa, RM (2007). Plastic corticostriatal circuits for action learning: What’s dopamine got to do with it?  In: Reward and Decision Making in Corticobasal Ganglia Networks Annals of the New York Academy of Sciences, 1104:172-91. 

  • Costa, RM, Drew, C and Silva, AJ (2005). To Remember or Notch to Remember. Trends in Neurosciences, 28, 429-35. 

  • Costa, RM and Silva, AJ (2003). Mouse models of Neurofibromatosis type I: Bridging the GAP. Trends in Molecular Medicine, 9, 19-23. 

  • Frankland, PW, Ohno M, Takahashi, E, Chen, AP, Costa RM, Kushner, SA and Silva, AJ (2003). Synomics:  Pharmacologically Regulated Induction of Silent Mutations (PRISM):  Combined pharmacological and genetic approaches for learning and memory. The Neuroscientist, 9:104-9. 

  • Costa, RM and Silva, AJ (2002). Molecular and cellular mechanisms underlying the cognitive deficits associated with Neurofibromatosis type I. Journal of Child Neurology, 17, 622-626. 

  • Silva, AJ, Elgersma, Y and Costa, RM (2001). From genes to therapies: the role of animal models. Clinical Neuroscience Research, 1, 187-193. 

  • Silva, AJ, Elgersma, Y and Costa, RM (2000). Molecular and Cellular Mechanisms of Cognitive Function: Implications for Psychiatric Disorders. Biological Psychiatry, 47, 200-210. 

Books, Book Chapters and Monographs

  • Yin HH and Costa, RM (2010). Striatal dopamine and glutamate in action: the generation and modification of adaptive behavior. in Frontiers in Neuroscience, The Role of Dopamine in the Basal Ganglia, ed. Susan Jones. Taylor & Francis Group, Boca Raton, FL, US. 

  • Lovinger, DM, Davies MI and Costa, RM (2009). Endocannabinoid Signaling in the Striatum. in Handbook of Basal Ganglia Structure and Function, ed. Heinz Steiner and Kuei Y. Tseng. Academic Press, London, UK. 

  • Costa, RM and Silva, AJ (2004). Learning Deficits associated with NF1: from models to therapies. in Neurofibromatose: Clínica, Genética e Terapêutica , Ed. Mauro Geller, Editora Guanabara Koogan SA, Rio de Janeiro, Brazil (Portuguese). 

  • Costa, RM, Elgersma, Y and Silva, AJ (2003). Modeling cognitive disorders: from genes to therapies. in Genetics and Genomics of Neurobehavioral Disorders, Ed. Gene Fisch, Humana Press, Totowa, NJ, USA

  • Costa, RM (2002). Molecular and cellular mechanisms of cognitive dysfunction in Neurofibromatosis type I. Thesis. Abel Salazar Biomedical Institute, University of Porto, Portugal.